Besides pH and dissolved oxygen measurements, reliable monitoring and control of the CO2 partial pressure is important for successful fermentation. At high viable cell concentrations the accumulation of CO2 can become very problematic. High CO2 concentrations can inhibit cell growth and alter the glycosylation of pattern of recombinant proteins. METTLER TOLEDO’s CO2 sensors delivers precise, real-time data that increases the understanding of critical fermentation and cell culture processes.
METTLER TOLEDO’s InPro 5000i dissolved CO2 sensor allows for the accurate measurement and control of dissolved carbon dioxide in biopharmaceutical applications. The measuring principle is based on the Severinghaus principle of potentiometric CO2 measurement which has been widely accepted for over 55 years. The high surface finish of the stainless steel sensor prevents contamination and the sensor is fully sterilizable either in-situ or in an autoclave. The design of the membrane dramatically reduces full service time to just minutes. The interior body, a high performance pH electrode, can easily be replaced at your site. No need to send the sensor in for service.
Sterilizable and autoclavable, the 5000i is engineered to meet or exceed all FDA and GMP requirements, with 3-A, EHEDG, 3.1B, and FDA 21 CFR 177 compliance. Intelligent Sensor Management (ISM) sensor technology provides a true plug-and-measure digital transmitter interface with extensive sensor diagnostics and life-cycle monitoring. Interface the sensor to your bioreactor with one of Ingold’s many stationary or retractable housing designs. Complete your dissolved CO2 measurement with a suitable cable and transmitter.
When considering Dissolved Carbon Dioxide (CO2) sensor features the following attributes should be taken into account: