Entegris is designed to maximize simplicity, ease-of-use and affordability. It stores, recirculates and mixes all types of solutions within a sterile single-use mixing bag. The only additional equipment required is an outer rigid container, a mixing stabilizer and a peristaltic pump. The rapid recirculation design will mix to a homogeneous mixture, saving time and money without sacrificing quality or consistency.
The system works by using a disposable mixing nozzle to direct recirculation fluids throughout the single-use mixing bag. The bag is fitted inside a reusable rigid outer container. Using the mixing nozzle design, multiple tubing sizes and the conical-shaped container, the mixing system creates either a gentle or robust turbulent mixing that sweeps and lifts the contents from the bottom of the bag. The recirculation action is accomplished using an external peristaltic pump, which helps minimize capital expenses. If the system needs to be mobile, a tank dolly and cart for the pump can be utilized.
Because the bag is disposable, cleaning validation between batches is eliminated, removing the documentation burden from your quality team. The closed system design reduces cross-contamination risk between batches, supporting process validation and a defensible audit trail.
Sentinel Process Systems, Inc. has experience servicing our clients dating back to 1950, we can answer your questions about these solutions and make recommendations based on your application requirements.
Peristaltic pumps drive recirculation by compressing and releasing flexible tubing, advancing process fluid through the disposable flow path. The reusable pump minimizes capital investment and carries forward to subsequent campaigns without requalification. Its low-shear pumping action is gentle enough for sensitive cell culture media and feed components while generating sufficient force for powder-to-liquid dissolution and large-volume buffer preparation.
Single-use mixing systems use different agitation approaches:
Key features of the Entegris Mixing System include:
Entegris manufactures its Mixing System to the most exacting standards. Your Entegris Mixing System is backed by:
The Entegris Mixing System is suitable for various uses:
Since single-use mixing systems often provide bag assemblies in different sizes, identifying your working volume range before ordering enables more efficient mixing and minimizes holdup losses at the end of each run. Thermal requirements are also worth considering. If your application involves temperature-sensitive materials or requires controlled storage conditions during mixing, choose a system that offers a temperature-controlled tank.
Experience the benefits of recirculation-based mixing with the Entegris Mixing System. Contact Sentinel Process Systems today to speak with an expert about your application needs.
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